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BIOCHEMICAL EFFECT OF FIBRINOGEN

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BIOCHEMICAL EFFECT OF FIBRINOGEN

 

CHAPTER ONE

 

1.0     Introduction

 

1.1     Fibrinogen

 

1.1.1  Fibrinogen Synthesis

 

1.1.2  Functions of Fibrinogen

 

CHAPTER TWO

 

2.0     Types of fibrinogen disorders

 

2.1     Clinical manifestations

 

2.1.1  Hypofibrinogenemia

 

2.1.2  Dysfibrinogenemia

 

2.2     Laboratory diagnosis

 

2.2.1  Molecular diagnosis

 

2.2.2  Dysfibrinogenemia mutations

 

2.2.3  Prenatal diagnosis

 

CHAPTER THREE

 

3.0     Fibrinogen Replacement

 

3.1     Fresh Frozen Plasma

 

3.2     Cryoprecipitate

 

3.3     Fibrinogen Concentrate

 

3.4     Current understanding of fibrinogen replacement

 

3.4.1  Preclinical Data

 

3.4.2  Clinical Data

 

3.4.2.1 Trauma

 

3.4.2.2 Perioperative Bleeding

 

CHAPTER FOUR

 

4.0     Conclusion and Recommendation

 

4.1     Conclusion

 

4.2     Recommendation

 

References.

 

 

 

 

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